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KMID : 0380620080400050545
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Korean Journal of Food Science and Technology
2008 Volume.40 No. 5 p.545 ~ p.550
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Enhancement of Immunomodulatory Activities of Low Molecular Weight Fucoidan Isolated from Hizikia fusiforme
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Ha Ji-Hye
Kwon Min-Chul
Han Jae-Gun
Kim Ryung
Jung Hyang-Suk
Choi Geun-Pyo
You Sang-Guan
Lee Hyeon-Yong
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Abstract
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The anticancer and immunomodulatory activities of low molecular weight (Mw 11 kDa) fucoidan isolated from Hizikia fusiforme (H. fusiforme) via the ultrasonification extraction process were assessed in this study. Low molecular weight fucoidan improved the growth of human B and T cells, up to approximately 40% as compared to the controls (untreated) and 30% for commercially available fucoidan (Mw 150 kDa). IL-6 and TNF-α were secreted from human B cells at levels of 7.8×10?4 pg/mL and 7.2×10?4 pg/mL, respectively, and these levels were higher than the levels measured in the controls and with other high molecular weight fucoidan. It was also determined that the cytokine from human B and T cells cultivated with added fucoidan enhanced the growth of human NK cells. The fucoidan isolated from H. fusiforme showed low cytotoxicity, approximately 19%, after the addition of 1.0 mg/mL, the highest tested concentration. The growth of human lung cancer cells (A549) and human breast cancer cells (MCF-7) were inhibited by 69.8% and 83.3%, respectively. These results demonstrated that the low molecular weight fucoidan isolated from H. fusiforme has potential as a new functional food component that evidences immunomodulatory activities and anticancer activity. One of the primary positive features of this fucoidan is that low molecular weight polysaccharides can be readily handled during processing.
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KEYWORD
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Hizikia fusiforme, low molecular weight fucoidan, immune activities
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